Organic Chemistry Fourth Edition文档.pptVIP

19.14Mechanism of Acid-Catalyzed Esterification Acid-catalyzed Esterification Important fact: the oxygen of the alcohol isincorporated into the ester as shown. Mechanism of Fischer Esterification The mechanism involves two stages: 1) formation of tetrahedral intermediate (3 steps) 2) dissociation of tetrahedral intermediate  (3 steps) Mechanism of Fischer Esterification The mechanism involves two stages: 1) formation of tetrahedral intermediate (3 steps) 2) dissociation of tetrahedral intermediate  (3 steps) First stage: formation of tetrahedral intermediate methanol adds to