肉芽肿性肺疾病的病理诊断课件.pdfVIP

Histopathology 2007, 50, 289–310. DOI: 10.1111/j.1365-2559.2006.02546.x REVIEW Pathological diagnosis of granulomatous lung disease: a review O A El-Zammar A-L A Katzenstein Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA El-Zammar O A Katzenstein A-L A (2007) Histopathology 50, 289–310 Pathological diagnosis of granulomatous lung disease: a review Granulomas in the lung are common diagnostic summarizes the main histological features that help problems encountered by pathologists. They occur in distinguish various granulomatous lung diseases. It a wide range of pulmonary conditions, ranging from concentrates on the most important and common common entities to uncommon ones and including entities that may be encountered and emphasizes both infections and non-infectious diseases. This review helpful features in the differential diagnosis. Keywords: granulomatous lung disease, lung granuloma, sarcoidosis, tuberculosis, Wegener’s granulomatosis Abbreviations: BOOP, bronchiolitis obliterans–organizing pneumonia; C-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies; FM, Fontana–Masson; GMS, Gomori methenamine silver; HE, haematoxylin and eosin; Mac, Mycobacterium avium complex; P-ANCA, perinuclear antineutrophil cytoplasmic antibodies; PAS, periodic acid-Schiff; PCR, polymerase chain reaction; TB, Tuberculosis Introduction ered to be histologically different from ‘caseating’, in that remnants of lung parenchyma or inflammatory The evaluation of granulomatous lung lesions is a cells may be found in the former and are absent in the common