五种食用合成色素的遗传毒理学效应研究-癌变·畸变·突变.PDF

癌变·畸变·突变　　1999 年第 11 卷第 2 期　　　　　　　　　　　　　　　Carcinogenesis Teratogenesis and Mutagenesis Vol 11 No 2 1999 五种食用合成色素的遗传毒理学效应研究 1 2 林建城 　林素霞 1 2 莆田高等专科学校生化系 　福建莆田 　351100 　 莆田县医院 摘要 　本文采用生物学检测技术 ,对五种国产食用合成色素的遗传毒理学效应进行研究。结果表明 ,在一定剂量范围内 ,合 ( ) 成色素能明显诱发紫露草四分体微核率的提高 ,与对照组比较 ,达显著或极显著差异水平 P < 0. 05 或 P < 0. 01 ,并有一定的 剂量反应关系 , F 检验还显示这五种不同色素的四分体微核率间差异极显著。同时 ,五种色素同样能诱发蚕豆根尖细胞微核 ( ) 率的提高 ,高剂量实验组和对照组比效 ,均有极显著差异 P < 0. 01 。提示食用合成色素对植物性细胞和体细胞内的染色体 都具有诱变效应 ,一定剂量下呈较强烈的遗传毒理学效应。 合成色素 ;遗传毒理学 ;生物学检测 关键词 　 STUDY ON GENETICAL TOXICAL EFFECTS OF FIVE EDIBL E SY NTHETIC PIGMENTS 1 2 Lin Jiancheng , Lin Suxia 1 2 B iochemist ry Depart ment of Putian J unior College , Fujian Province 351100 , Putian Couty Hospital Abstract 　This article is about the study on genetical toxical effects of five homemade edible synthetic pigments by suing bioassay. Results showed that the synthetic pigments with certain dose range would evidently induce the increase of micronucleus frequencies of T radescantia Pal udosa tetrads , The micronucleus frequencies reached significant or highly significant difference as compared with control ( P < 0. 05 , P < 0. 01) , There was also the obvious doseresponse relationshop. F test also showed that significant difference of tetrad micronucleus frequencies induced by five pigments. Meanwhile they could induce the increase of micronucleus frequencies of V icia f aba roottip cells , the test indicated an ultimate difference between higher dose groups and the control group. The study suggested that the