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[理学]表观遗传学 1
Epigenetics —
Chromatin based gene control
Chaoqun Wu
School of Life Sciences,
Fudan University
2005-11-11 Chaoqun Wu, Fudan University 1
2005-11-11 Chaoqun Wu, Fudan University 1
Genomes and Gene Number
6000 19,000 13,500 30,000 27,000
Gene number
2005-11-11 Chaoqun Wu, Fudan University 2
2005-11-11 Chaoqun Wu, Fudan University 2
But if in the
Muscle cells
same organism,
should have the
same DNA per
Nerve cells cell
Different cells have different
clusters of genes active
Development and differentiation of embryos is
controlled by signaling molecules that alter
gene expression in cells.
2005-11-11 Chaoqun Wu, Fudan University 3
2005-11-11 Chaoqun Wu, Fudan University 3
2005-11-11 Chaoqun Wu, Fudan University 4
2005-11-11 Chaoqun Wu, Fudan University 4
Genome is packaged into chromatin
2005-11-11 Chaoqun Wu, Fudan University 5
2005-11-11 Chaoqun Wu, Fudan University 5
Basic unit is nucleosome:
Consists of a core octamer of histones H2A,
H2B, H3 and H4 (2X). Approximately 150 bp DNA
wrapped 2X around outside of nucleosome
2005-11-11
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