Chapter15 B cell mediated immune response(学习资料).ppt

Chapter 15 B cell mediated immune response Chapter 15 B cells mediated immune response Humoral immunity(HI) or antibody mediated immunity: The total immunological reaction that B cells recognize antigen, then activate, proliferate, differentiate into plasma cells and produce Ab. B2 cells mediated immune response to TD-Ag B1 cells mediated immune response to TI-Ag Contents PartⅠ Immune response of B2 cell to TD-Ag PartⅡ Rules of humoral immunity PartⅢ Immune response of B1 cell to TI-Ag PartⅣ Signal transduction of T and B cells PartⅠ Immune response of B2 cell to TD-Ag Characteristics of TD-Ag: Most native Ag Protein, large molecules Possess T cell epitope and B cell epitope Both CMI and HI Need Th cells participation Produce several types of antibodies: IgG Produce immune memory PartⅠ Immune response of B2 cell to TD-Ag B2 cells recognize TD-Ag  activate, proliferate, differentiate plasma cells produce Ab 1.??B cells recognize antigen BCRs directly recognize the epitope on the surface of Ag No APC , no MHC restriction Capture Ag by BCR, present Ag signal to T cells 2. B cells activation, proliferation and differentiation (1) B cell activation: dual signals First signal: antigen signal BCR-- determinant on the surface of Ag Igα/Igβtransduct the first signal CD19/CD21/CD81 (co-receptor) binds to C3dg on Ag Second signal: co-stimulatory signal The CD40 on B cells binds to CD40L on activated Th cells Interaction between Th cells and B cells B cells act on Th cells: B cells present Ag to Th cells. B cells provide B7 for Th cells. Th cells act on B cells: Activated Th cells provide co-stimulatory molecule for B cells: CD40L- CD40. Activated Th cells secrete Cks（IL-4、IL-5、IL-6、IL-10、IL-13）which help B cells proliferate and differentiate. (2) B cells proliferation and differentiation------help of Th cells Activated B cells express