Lineage Specific Transcriptional Regulation of DICER by MITF…对的特定转录调控.pdfVIP

Lineage-Specific Transcriptional Regulation of DICER by MITF in Melanocytes Carmit Levy,1 Mehdi Khaled,1 Kathleen C. Robinson,1 Rosa A. Veguilla,1 Po-Hao Chen,2 Satoru Yokoyama,1 Eiichi Makino,1 Jun Lu,3,4,5 Lionel Larue,6 Friedrich Beermann,7 Lynda Chin,8 Marcus Bosenberg,9 Jun. S. Song,10,11 and David E. Fisher1,* 1Department of Dermatology, Cutaneous Biology Research Center, Mass. General Hospital, Harvard Medical School, MA 02115, USA 2Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA 3Broad Institute, Cambridge, MA 02141, USA 4Department of Pediatric Oncology, Dana–Farber Cancer Institute, Boston, MA 02115, USA 5Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA 6Institut Curie, Developmental Genetics of Melanocytes, UMR 146 CNRS, Bat. 110, 91405, Orsay Cedex, France 7EPFL SV ISREC, Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland 8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA 9Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA 10The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA 11Present address: Institute for Human Genetics, The University of California, San Francisco, CA 94143, USA *Correspondence: dfisher3@partners.org DOI 10.1016/j.cell.2010.05.004 SUMMARY Du and Zamore, 2007; Filipowicz et al., 2008; Maroney et al., 2006; Neilson and Sharp, 2008; Schier and Giraldez, 2006). DICER is a central regulator of microRNA maturation. Numerous fundamental processes, including development, However, little is known about mechanisms regu- differentiation, and tumorigenesis, are regulated by miRNAs lating its expres