Research Article Flavonoids Induce the Synthesis and Secretion…研究论文黄酮类化合物诱导合成和分泌.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 127075, 10 pages /10.1155/2013/127075 Research Article Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes: A Signaling Response Mediated by Estrogen Receptor Sherry L. Xu, Cathy W. C. Bi, Roy C. Y. Choi, Kevin Y. Zhu, Abudureyimu Miernisha, Tina T. X. Dong, and Karl W. K. Tsim Division of Life Science and Center for Chinese Medicine, he Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Correspondence should be addressed to Karl W. K. Tsim; botsim@ust.hk Received 23 April 2013; Revised 30 May 2013; Accepted 10 June 2013 Academic Editor: Paul Siu-Po Ip Copyright 漏 2013 Sherry L. Xu et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders. Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneicial efects. Here, the efects of lavonoids on regulating neurotrophic factors were analyzed in cultured rat astrocytes. Astrocyte is a major secreting source of neurotrophic factors in the brain. hirty-three lavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identiied to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial- derived neurotrophic