A new marine-derived sulfated polysaccharide from brown alga suppresses tumor metastasis推荐.pdfVIP
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A new marine-derived sulfated polysaccharide from brown alga suppresses tumor metastasis推荐
[Cancer Biology Therapy 5:11, 1474-1480, November 2006]; ©2006 Landes Bioscience
Research Paper
A New Marine-Derived Sulfated Polysaccharide from Brown Alga
Suppresses Tumor Metastasis Both in Vitro and in Vivo
Xuelian Tang† ABSTRACT
Jing Li† Herein, we report that marine-derived sulfated polysaccharide (MSP), a new kind of
polysaccharide extracted from brown alga, exhibits the anti-migration effect in vitro and
Xianliang Xin potently suppress metastasis of Lewis lung carcinoma in vivo. Adhesion assays demonstrated
that MSP inhibits the heterogenous adhesion on fibronectin. Further studies revealed that
Meiyu Geng* .
MSP decreased FN-induced MDA-MB-435 migration, accompanied by its potent regulatory
E
Department of Molecular Pharmacology and Glycobiology; School of Medicine and effect on actin filament reassembling. In addition, MSP significantly inactivated the
T
Pharmacy; Ocean University of China; Qingdao, P.R. China phosphorylation of FAK and subsequent ERK1/2 in MDA-MB-435 cells. All these actions
U
†These two authors contribute equally to this work. may be the results of MSP binding to FN, promising the therapeutic potential of MSP in
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