Alcohol consumption and all-cause mortality推荐.pdfVIP

Addiction (1995) 90, 471^8 0 RESEARCH REPORT Alcohol consumption and all-cause mortality JURGEN REHM CHRISTOPHER T . SEMPOS Swiss Institute for the Prevention of Alcohol and Drug Problems, Lausanne, Switzerland and ^National Center for Health Statistics, Centers for Disease, Control and Prevention, Hyattsville, Maryland, USA Abstract Based on a large US representative cohort with detailed baseline interview and examination data, the relationship between alcohol consumption and all-cause mortality is examined over a period of 15 years follow-up. Results show a significant linear relationship for females and males under 60 years of age at baseline, and a non-significant U-shape for the older ones. Both results remain stable for different kinds of adjustment including adjustment for nutritional variables and smoking. Excluding people with heart disease history at baseline leads to an even more pronounced linear relationship for both males and females under 60 years of age. Furthermore, it is shown that the curvilinear relationship for men found in previous research is partly due to the age groups examined. Introduction Studies (Hirayama, 1990; Klatsky, Amstrong For a number of years the relationship between Friedman, 1992) as well as a recent meta- alcohol consutnption and mortality has been in analysis of prospective studies (Duffy, 1992b) the focus of attention (for overviews see Ander- came to the conclusion that a U-shaped relation- son et al., 1993; Beaglehole Jackson, 1992; ship exists. Duffy, 1992a; Rehm, 1993). While many studies Criticism has been brought forward that