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5 Automated SPME Systems a b a Janusz Pawliszyn , Dajana Vuckovic , Fatemeh Mirnaghi and Sanja Risticevica aDepartment of Chemistry, University of Waterloo, Waterloo, Ontario, Canada bDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada 5.1 Automated Solid-Phase MicroextractionGas Chromatography The fibre configuration of solid-phase microextraction (SPME) is best suited for automation with gas chromatography (GC), due to its similarity to the traditional GC syringe for liquid injection. In principle, any autosampler that is able to per- form syringe injection can be modified to be capable of automated SPMEGC. The first commercial version of the laboratory SPME device was introduced by Supelco in 1993 (see Figure 4.3 in Chapter 4). In addition to standard PDMS coat- ings of various thicknesses and polyacrylate, Supelco developed new mixed phases based on solid/liquid sorption, such as Carbowaxs, CARPDMS, polydimethylsi- loxanedivinylbenzene (PDMSDVB) and DVBCARPDMS. New coatings and devices are expected to follow as interest in SPME grows, along with the unprecedented number of new applications appearing in the literature. 5.1.1 Automation of Fibre SPMEGC The first reference in the literature to automated SPME analysis was by Arthur et al.,1 published even before the first commercial SPME fibres were released. This work involved adapting a Varian model 8100 syringe autosampler so that it could accept an SPME device. Magnetic stirring was used for agitation. This was achieved by setting up a microstirrer so that it would be in close proximity to the vial being sampled. The first commercial GC autosampler with a capability for SPME was the