Bio-mining the microbial treasures of the ocean New natural products推荐.pdfVIP

Biotechnology Advances 29 (2011) 468–482 Contents lists available at ScienceDirect Biotechnology Advances j ournal homepage: www. elsevier. com/ locate/ biotechadv Research review paper Bio-mining the microbial treasures of the ocean: New natural products Johannes F. Imhoff ⁎, Antje Labes, Jutta Wiese Kieler Wirkstoff-Zentrum am Leibniz-Institut für Meereswissenschaften IFM-GEOMAR, Düsternbrooker Weg 20, 24105 Kiel, Germany a r t i c l e i n f o a b s t r a c t Available online 17 March 2011 The biological resources of the oceans have been exploited since ancient human history, mainly by catching fish and harvesting algae. Research on natural products with special emphasis on marine animals and also Keywords: algae during the last decades of the 20th century has revealed the importance of marine organisms as Marine bacteria producers of substances useful for the treatment of human diseases. Though a large number of bioactive Marine fungi substances have been identified, some many years ago, only recently the first drugs from the oceans were Bioassays approved. Quite astonishingly, the immense diversity of microbes in the marine environments and their Natural products Microbial interactions almost untouched capacity to produce natu