深刻认识COPD急性加重精选.pptVIP

* COPD在气道慢性炎症的基础上，在微生物、污染等诱发因素的作用下，气道炎症加剧，引起支气管狭窄，水肿，粘液分泌增加，从而导致呼气性气流受限，肺动态过度充气，出现急性加重症状。另一方面，肺部炎症溢出，导致全身性的炎症反应。 COPD exacerbations are associated with increased upper and lower airway and systemic inflammation. The airway inflammatory responses cause oedema, bronchospasm, and increased sputum production, leading to worsening airflow limitation and development of dynamic hyperinflation, which is a main cause of dyspnoea, the most common symptom of an exacerbation. Systemic inflammation increases at exacerbation and although the causes of this response in COPD are not clear, there is probably a