瞬时受体电位通道精选.pptVIP

Effect of CCB/SKF on Angiotensin II-induced aortic contraction and calcium increase in VSMC from SHR Vasomotion occurs in arteries either spontaneously or in response to pressure, stretch or application of vasoconstrictor agonists, which is associated with slow oscillations of smooth muscle membrane potential and of intracellular calcium concentrations. Vasomotion may also be enhanced by oscillations of transplasmamembrane calcium influx. TRP channels have been described to play an important role for calcium influx. What is pathophysiological relevance of vasomotion ? In several experi