原创力文档discovery of potent n-(isoxazol-5-yl)amides as hsp90 inhibitors：（发现强有力的n -(isoxazol-5-yl)酰胺一半抑制剂）.pdfVIP
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discovery of potent n-(isoxazol-5-yl)amides as hsp90 inhibitors：（发现强有力的n -(isoxazol-5-yl)酰胺一半抑制剂）
European Journal of Medicinal Chemistry 87 (2014) 765e781
Contents lists available at ScienceDirect
European Journal of Medicinal Chemistry
journal homepage: /locate/ejmech
Original article
Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors
a, 1 b, 1 c, 1 a d a
Danqi Chen , Aijun Shen , Jian Li , Feng Shi , Wuyan Chen , Jing Ren ,
Hongchun Liu b, Yechun Xu d, *, Xin Wang a, Xinying Yang b, Yiming Sun b, Min Yang c,
Jianhua He c, Yueqin Wang b, Liping Zhang e, Min Huang b, Meiyu Geng b, *, Bing Xiong a, *,
Jingkang Shen a, *
a Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
555 Zuchongzhi Road, Shanghai 201203, China
b Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
555 Zuchongzhi Road, Shanghai 201203, China
c Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China
d Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
e Department of Pharmacology and Glycobiology, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003,
Peoples Republic of China
a r t i c l e i n f o a b s t r a c t
Article history: HSP90 is ubiquitously overexpressed in a broad spectrum of human cancers and has been recog
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