discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4d (kdm4d) inhibitors：（(1、5)发现pyrazolo pyrimidine-3-carbonitrile衍生品作为一种新的组蛋白赖氨酸demethylase 4 d(kdm4d)抑制剂）.pdfVIP

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discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4d (kdm4d) inhibitors：（(1、5)发现pyrazolo pyrimidine-3-carbonitrile衍生品作为一种新的组蛋白赖氨酸demethylase 4 d(kdm4d)抑制剂）.pdf

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discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4d (kdm4d) inhibitors：（(1、5)发现pyrazolo pyrimidine-3-carbonitrile衍生品作为一种新的组蛋白赖氨酸demethylase 4 d(kdm4d)抑制剂）

Bioorganic Medicinal Chemistry Letters xxx (2017) xxx–xxx Contents lists available at ScienceDirect Bioorganic Medicinal Chemistry Letters journal homepage: www.else /locate/bmcl Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors Zhen Fang a,d, Tian-qi Wang b,d, Hui Li a, Guo Zhang c, Xiao-ai Wu a, Li Yang a, Yu-lan Peng a, Jun Zou a, Lin-li Li c, Rong Xiang b,⇑, Sheng-yong Yang a,⇑ a Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China b Department of Clinical Medicine, School of Medicine, Nankai University, Tianjin 300071, China c Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 61004 1, China a r t i c l e i n f o a b s t r a c t Article history: Herein we report the discovery of a series of new small molecule inhibitors of histone lysine demethylase Received 26 January 2017 4D (KDM4D). Molecular docking was ﬁrst performed to screen for new KDM4D inhibitors from various Revised 17 April 2017 chemical databases. Two hit compounds were retrieved. Further structural optimization and structure- Accepted 1 May 2017 activity relationship (SAR) analysis were carried out to the more selective one, compound 2, which led Available online xxxx to the discovery of several new KDM4D inhibitors. Among them, compound 10r is the most potent