discovery of pyridine-based agrochemicals by using intermediate derivatization methods：（发现pyridine-based农用化学品使用中间衍生化方法）.pdfVIP

Bioorganic Medicinal Chemistry 24 (2016) 342–353 Contents lists available at ScienceDirect Bioorganic Medicinal Chemistry journal homepage: www.else /locate/bmc Discovery of pyridine-based agrochemicals by using Intermediate Derivatization Methods Ai-Ying Guan a,b, Chang-Ling Liu b,⇑, Xu-Feng Sun b, Yong Xie b, Ming-An Wang a,⇑ a Department of Applied Chemistry, China Agricultural University, Beijing 100193, China b State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd., Shenyang 11002 1, China a r t i c l e i n f o a b s t r a c t Article history: Pyridine-based compounds have been playing a crucial role as agrochemicals or pesticides including Received 29 June 2015 fungicides, insecticides/acaricides and herbicides, etc. Since most of the agrochemicals listed in the Revised 15 September 2015 Pesticide Manual were discovered through screening programs that relied on trial-and-error testing Accepted 17 September 2015 and new agrochemical discovery is not benefiting as much from the in silico new chemical compound Available online 21 September 2015 identification/discovery techniques used in pharmaceutical research, it has become more important to find new methods to enhance the efficiency of discovering novel lead compounds in the agrochemical Keywords: field to shorten the ti