原创力文档discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance：（发现潜在的抗癌多靶向川芎嗪环己酮和肟类似物克服肿瘤多药耐药性）.pdfVIP
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discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance：（发现潜在的抗癌多靶向川芎嗪环己酮和肟类似物克服肿瘤多药耐药性）
European Journal of Medicinal Chemistry 135 (2017) 34e48
Contents lists available at ScienceDirect
European Journal of Medicinal Chemistry
journal homepage: http://www.elsevier .com/locate/ejmech
Research paper
Discovery of potential anticancer multi-targeted ligustrazine based
cyclohexanone and oxime analogs overcoming the cancer multidrug
resistance
a, 1 a, ** b, c d
Gao-Feng Zha , Hua-Li Qin , Bahaa G.M. Youssif , Muhammad Wahab Amjad ,
Maria Abdul Ghafoor Raja d, Ahmed H. Abdelazeem e, Syed Nasir Abbas Bukhari a, b, *, 1
a Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi
Road, Wuhan, 430070, PR China
b Department of Pharmaceutical Chemistry, College of Pharmacy, Aljouf University, Aljouf, Sakaka 2014, Saudi Arabia
c Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
d College of Pharmacy, Northern Border University, King Abdullah Road, Rafha, Saudia Arab
e Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
a r t i c l e i n f o a b s t r a c t
Article history: The drug research and development nowadays is focusing on multi-target drugs. In the treatment of
Received 1 February 2017 cancer, therapies using drugs inhibiting one numerous targets signify a novel viewpoint. In comparison
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