dualistic immunomodulation of sub-chronic microcystin-lr exposure on the innate-immune defense system in male zebrafish：（二元的免疫调节sub-chronic美国男性斑马鱼暴露在先天免疫防御系统）.pdfVIP

Chemosphere 183 (2017) 315e322 Contents lists available at ScienceDirect Chemosphere journal homepage: /l ocate/chemosphere Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish Wang Lin a, Jie Hou a, Honghui Guo a, Yuming Qiu a, Li Li a, b, c, d, *, Dapeng Li a, b, c, d, Rong Tang a, b, c, d a College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China b Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan 430070, PR China c Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, PR China d Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Wuhan 430070, PR China h i g h l i g h t s g r a p h i c a l a b s t r a c t Macrophages might be the main ac- tion site of MC-LR in the spleen. MC-LR has concentration-dependent dualistic influences on fish innate immune system. Inflammatory activation in low exposure concentration but immune inhibition at high concentration. Interference of environmental con- centrations of MC-LR in the immune system should not be neglected. a r t i c l e i n f o a b s t r a c t Article history: Microcystins (MCs), produced by toxic cyanobacterial blooms that appeared world wildly in eutrophication Received 13 March 2017 waters, have often caused fish illness and even massive death cases. Among at least 90 structural variants, Received in revised form microcystin-LR (MC-LR) is the most common and toxic variant. In order to better understand inn