抗生素与SFGH(英文课件)Antibiotics at SFGH.pptVIP

The potential for drug interactions must always be considered Most of the newer agents have low affinity for the hepatic cytochrome P450 system or are excreted renally There are reports that polyvalent cations can reduce the oral bioavailability of quinolones anywhere from 10-50%, especially when given concomitantly This is a problem especially in patients on multiple medications such as the elderly or ICU patients QT prolongation? Check patient profiles! Antibacterial resistance in several important groups of microbial pathogens appears to be correlated with the use of fluoroquinolones. T