第三节克隆新基因.pptVIP

一、图位克隆法 Positional Cloning Before the genomics era, geneticists seeking the genes responsible for human genetic disorders frequently faced a problem: They did not know the identity of the defective protein, so they were looking for a gene without knowing its function. Thus, they had to identify the gene by finding its position on the human genetic map. Positional cloning ——The process that commences with searching for markers linked to a particular inherited trait, then using those markers to identify the approximate location of the gene responsible for the trait, and then using