(精选)中西医结合免疫学 第五章 补体系统课件.pptVIP

C3a C3a Bb C3b Bb Bb C3a C3-activationthe amplification loop C3b C3b C3a C3a Bb C3b Bb Bb C3a C3-activationthe amplification loop C3b C3b C3b stabilization andC5 activation C3b C3b finds an activator (protector) membrane C3 C3a b C5 b C5a B D b P This leads to formation of membrane attack complex 旁路途径激活特点 体内C3自发水解成C3b，使旁路途径处于准激活状态 旁路途径能识别自己与非己 旁路途径是补体系统重要放大机制 补体活化的共同终末效应 C5转化酶启动终末成分（C5、6、7、8、9）活化MAC导致靶细胞的溶解。 C5转化酶 C5 C6 C7 C8 （n=12-16）nC9 C5b C5a C5b6 C5b67 C5b6789 （MAC） C5- convertase of the three pathways C3b Bb C3b C5-convertase of the Alternative