(精编)【英文教学精品课件】Nephron number and essential hypertension – factors responsible for nephron load at the time of birth教学课件.pptVIP

* * * * * * * * * * * * * * * Maternal protein restriction suppresses the newborn RAS and programs adult hypertension(Woods et al., Ped Res 2001) Maternal protein restriction suppresses the newborn RAS and programs adult hypertension NP LP Pax-2 ? ? apoptosis? (Woods et al., Ped Res 2001) Placental 11?-HSD2 (Hydroxysteroid Dehydrogenase) expression in relation to birth weight (Schoof et al., J Clin. Endocrinol. Metab. 2001) 2000 2500 3000 3500 4000 4500 0,0 0,5 1,0 1,5 2,0 Birth weight (g) 11 b -HSD2/GAPDH (relative units) r=0,43 p=0,001 ? converts cortisol to the biologically less act