(精编)Antimicrobials教学课件.pptVIP

Antimicrobials;Antimicrobial Agents;;Historical Perspective of Antibiotics;Your Basic Bacteria;Antibiotic Targets;Antibiotic Targets;Antimicrobial Drugs Mode of Action;Antimicrobial Drugs Modes of Action;Types of Antimicrobial Resistance;Mechanisms of Resistance; Efflux mechanisms Acquisition of an inner membrane protein which actively pumps the antibiotic out of the cell. E. coli acquires resistance to tetracyclines Alternative pathway Bacteria acquire a gene to code an alternative penicillin binding protein which is not inhibited. Alteration of the target site Point mutations, insertio