(精编)combination monotherapy in treatment of carbepenem resistant acinetobacter baumanii crab infections 2016教学课件.pptVIP

Combination vs. Monotherapy in treatment of Carbapenem Resistant Acinetobacter baumanii (CRAB) infections;Learning Objectives: ;Case:;Bad Bugs, No Drugs, No ESKAPE;CDC. Antibiotic Resistance Threats in the United States (2013). /drugresistance/threat-report-2013/;Resistance Terminology;50-70% of Ab clinical isolates are now extensively Drug Resistant (XDR; i.e. resistant to all antibiotics except colistin or tigecycline), reflecting a 15-fold increase since 2000. Number of PDR strains of Ab, resistant to tigecycline and colistin are increasing;Does resistance matter? ;Mortality: 16-76% ;Evol