树鼩的血压测定.docVIP

研究报告 树鼩血压和心率的无创测定 仝品芬1，陆彩霞2，江勤芳2，孙晓梅1,2，高家红2，匡德宣1，代解杰1,2, (1、中国医学科学院/北京协和医学院 医学生物学研究所树鼩种质资源中心；2、云南省重大传染病疫苗研发重点实验室，昆明 650118) 【摘要】 目的 建立健康树鼩的心率、血压正常值参考范围，并探讨不同来源、不同性别、不同年龄树鼩心率、血压的差异。方法 随机挑选实验树鼩180只，按来源分为野生成年组、F1代自繁成年组和青幼年组三个组，每组雌雄各半，共60只。采用智能无创血压计（鼠仪）逐只测定HR（心率）、SBP（收缩压）、DBP（舒张压）和MBP（平均动脉压）。结果 野生成年树鼩、自繁成年树鼩和青幼年树鼩心率分别为394.33±37.74 BPM、351.61±72.76 BPM和378.19±69.04 BPM，野生和自繁成年树鼩组有显著 [关键词] 树鼩；心率；无创血压 【中图分类号】R33【文献标识码】A【文章编号】1671-7856（201）-0000-00 Doi:10.3969/j.issn.1671-7856.2013.004.000 Noninvasive measurement of heart rate and blood pressure in tree shrews TONG Pin-fen1, Lu Cai-xia2, JIANG Qin-fang2 , Sun Xiao-mei1,2, GAO Jia-hong2, KUAN De-xuan1, DAI Jie-jie1,2 (1. the Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medicine Sciences (CAMS) Peking Union Medical College (PUMC), 2.Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Diseases, Kunming 650118) [Abstract] Objective To establish the normal reference values of heart rate (HR) and blood pressure (BP) of healthy tree shrews, and discuss the differences of HR and BP in tree shrews of different sources, sex and age. Methods One hundred eighty tree shrews were randomly divided in three groups: wild adult group, F1 generation artificial breeding adult group and juvenile group. Each group included 60 animals ( half female and half male). An indirect blood pressure meter（BP-98A）sed to measure the heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MBP). Results The HR of wild adult, artificial breeding adult and juvenile tree shrews were 394.33±37.74 BPM, 351.61±72.76 BPM, and 378.19±69.04 BPM, respectively. There was a significant 【作者简介】仝品芬（1967-），女，主管技师，主要研究方向：动物实验，E-mail: 1254489442@。 【通讯作者】代解杰，男，研究员，主要研究方向：医学实验动物学。 difference between the wild adult and artificial breeding adult tree shrew groups (P0.05). The SBP, DBP and MBP of artificial breedin