氢气和甲烷呼气试验_6.pdfVIP

doi:10.1111/j.1440-1746.2010.06370.x GASTROENTEROLOGYjgh_6370 1366..1373 Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome Derrick K Ong,*,† Shaylyn B Mitchell,*,† Jacqueline S Barrett,* Sue J Shepherd,* Peter M Irving,* Jessica R Biesiekierski,* Stuart Smith,† Peter R Gibson* and Jane G Muir* *Department of Medicine, Eastern Health Clinical School, Monash University, and †School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia Key words Abstract breath testing, carbohydrates, dietary therapy, FODMAPs, gastrointestinal symptoms, Background and Aim: Reduction of short-chain poorly absorbed carbohydrates irritable bowel syndrome. (FODMAPs) in the diet reduces symptoms of irritable bowel syndrome (IBS). In the present study, we aimed to compare the patterns of breath hydrogen and methane and Accepted for publication 26 April 2010. symptoms produced in response to diets that differed only in FODMAP content. Methods: Fifteen healthy subjects and 15 with IBS (Rome III criteria) undertook a Correspondence single-blind, crossover intervention trial involving consuming provided diets that were Dr Jane Muir, Department of Medicine, either low (9 g/day) or high (50 g/day) in FODMAPs for 2 days. Food and gastrointestinal Monash University, Level 1-5 Arnold St, Box symptom diaries were kept and breath sampl