自身免疫性疾病-2015-英五班.ppt

Other genes C1q, C4 gene deficiency：SLE DNase deficiency ：SLE mutant CTLA-4：Diabetes 4. Other factors Gender Age Environment factor IV. Immunological control strategies Deletion factors which induce abnormal self-tolerance Inhibition of immune response to autoAg Rebuilding self-tolerance Control of infection Administration of immunosuppressive drug Antibodies autoAg …… Autoreactive T cell Synovial fibroblast M? IFN-?, IL-17 IL-1, IL-15 IL-1, TNF-? Chondrocyte Osteoclast MMPs, IL-6, IL-8, GM-CSF Cartilage and bone destruction TNF inhibitors IL-1 inhibitor IL-6 inhibitor Oral t