虫媒病毒 病毒性出血热 - 复旦大学精品课程.pdfVIP

Arthropod-borne viruses (Arboviruses) rodent-borne viruses (虫媒病毒 病毒性出血热) Shibo Jiang (姜世勃) MOHMOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学上海医学院分子病毒学教育部/卫生部重点实验室 Comparison of arthropod- and rodent-borne viruses Viruses arthropod-borne viruses rodent-borne viruses Reservoir hosts arthropods (e.g., mosquitoes, and rodents (e.g., mice, rats, ticks) squirrels, and hamsters) bloodsucking arthropods from one contact with body fluids or Transmitted by vertebrate host to another excretions of rodents yellow fever, dengue, Japanese B hantavirus infections, encephalitis, St. Louis encephalitis, Lassa fever, South Major diseases western equine encephalitis, eastern American hemorrhagic equine encephalitis, Russian spring- fevers, and African summer encephalitis, West Nile hemorrhagic fevers fever, and sandfly fever (Marburg and Ebola) Part I Arthropod-borne viruses (Arboviruses ) Overview  General information of arbovirus  Main properties of togaviruses (alphavirus)  Chikungunya caused by alphavirus  Main properties of flaviviruses  Dengue fever caused by flavivirus  Japanese B Encephalitis caused by flavivirus Arboviruses  Arboviruses spread by arthropod vectors, such as mosquitoes, ticks, and flies  It has four families: togaviruses, flaviviruses, bunyaviruses and reoviruses  The major arbovirus disease worldwide are yellow fever, dengue, Japanese B encephalitis, St. Louis encephal