没有标题浙江大学教学信息化平台.ppt

(2) Negative chronotropic effects Reflex inhibition of sympathetic activity cardiac output ? ? Sympathetic activity ? ? HR ? Increasing vagal activity directly Reducing AV conduction: ventricular rate ? E. Cardiac glycoside (digitalis) (3) Electrophysiological effects decreasing automaticity of sinoatrial node slow conduction, especially AV conduction increasing automaticity of Purkinje fibres shortening ERP of fast response cells Mechanisms: intracellular Na+ ?, K+ ?, Ca2+ ?? ? MDP ?, afterdepolarization