慢乙肝抗病毒治疗热点难点-特殊患者0705.ppt

Over 4 years of treatment, Hepsera results in increasing rates of HBV DNA undetectability and ALT normalization. The majority of these patients were maintained on lamivudine, as part of their HIV therapy. To date, no resistance to Hepsera has been identified in this population. * * Dore GJ, Cooper DA, Barrett C, Goh LE, Thakrar B, Atkins M. Dual efficacy of lamivudine treatment in human immunodeficiency virus/hepatitis B virus-coinfected persons in a randomized, controlled study (CAESAR). The CAESAR Coordinating Committee. J Infect Dis. 1999 Sep;180(3):607-13  * 在我国一般人群中HBV的感染率约为60%，由于乙