细菌感染概论(英文教学)Common Bacteria by Site of Infection重点培训.pptVIP

* * * * * * * * * * * * * * * * * * * * * Tigecycline Pharmacokinetics Metabolism: Hepatic, via glucuronidation, N-acetylation, and epimerization to several metabolites, each 10% of the dose Half-life elimination: Single dose: 27 hours; following multiple doses: 42 hours Excretion: Urine (33%; with 22% as unchanged drug); feces (59%; primarily as unchanged drug) – No dose adjustment required in renal dysfunction TigecyclineAdverse Effects 10%: Gastrointestinal: Nausea (25% to 30%), diarrhea (13%) 2% to 10%: Cardiovascular: Hypertension (5%), peripheral edema (3%), hypotension (2%) Central n