铱催化下的C-H键反应.pptxVIP

Unactivated Methyl C（sp3)-H Bonds High Stereoselective Intramolecular Silylation Reaction Bo Su; John F. Hartwig; J. Am. Chem. Soc.  2017, 139, 12137-12140. Speaker:Wang Wan Lin Date： 10.15.2017 Introduction Education Position 1986. B.A.Princeton Univ 1990. Ph.D.Chemistry, Univ.of California,Berkeley 1992. American Cancer Society Postdoctoral Associate, Massachusetts Institute of Technology 2011-present. Univ. of California, Berkeley, and Senior Faculty Scientist, Lawrence Berkeley National Laboratory Hartwig, John F. Professor Introduction Awards Honors 2010. GlaxoSmithKline Scholars Award 2009. National Institutes of Health MERIT Award 2009. Mitsui Chemicals Catalysis Science Award, Japan 2009. Joseph Chatt Award of the Royal Society of Chemistry 2008. Mukaiyama Award from the Society of Synthetic Organic Chemistry, Japan 2008. International Catalysis Award, International Association of Catalysis Societies 2008 . Paul N. Rylander Award 2007. Young Investigator Award 2007. Raymond and Beverly Sackler Prize in the Physical Sciences 2006. ACS Award in Organometallic.Chemistry 2004. Thieme-IUPAC Award 2003. Leo Hendrik Baekeland Award 1998. A.C. Cope Scholar Award Research areas Focuses on the discovery and understanding of new reactions of organic compounds catalyzed by transition metal complexes. Background Representative biologically active silicon-containing molecules. In 2013, Takai, Kuninubu, and co-workers published the first enantioselective silylation of aromatic C（sp2)−H bonds. In 2015, Shibata, He, and Takai, He wei independently reported enantioselective silylations of aromatic C（sp2)−H bonds that form chiral ferrocenes catalyzed by Rh complexes of chiral bisphosphine or diene ligands. Author group reported Rh-catalyzed enantioselective silylations of aromatic C(sp2)−H bonds in diarylmethanols and silylations of cyclopropyl C(sp3)−H bonds So far, only the Kazuhiko Takai group repor