二味中药复方治疗腹泻型肠易激综合征的实验研究.pdfVIP

2011 51 8 * , , , (赣南医学院, 江西赣州341000) : 6: , , , ; ; , : ; ; ; : R5 414 : A : 1002-266X( 2011) 08-0033-03 Effec t o f LW ZY on m o tility and cho lecystostomy in ra ts w ith d iarrhea p redom inant irritab le bow e l syndrom e ZHAN G D ao-y ing, LI H ong-liang, FAN X iao-na, ZEN G J ing ( Gannan M edical Un iversity, Gan hou 341000, P 1 R 1 China ) A b stract: O bjective To observe the effect of LW ZY decoction on m odel ratswhich had diarrhea predom inant irrita- b le bow el syndrom e ( IBS) w ith liver depression and spleen deficiency1 M ethods The ratmodel used in integer study w as / w rap-restrain t stress0 after perfused sennae solution1 The treatm ent lasted days1 The decoction had smal,l m iddle and large dose level1 The levels ofm otility (MOT) and cholecystostom y ( CCK ) in plasm a and descending colon tissuew ere ob- served1 Resu lts M idd le and h igh dose of LWZY cou ld sign ificantly change the rat loose stools class1 IBS m odel rats had a higher content of CCK in colon tissue, and the decoction of LW ZY cou ld modu late it to be norm al1 ButMOT had no s ignif-i cant changes neither in plasma nor in tissue1 Conc lusion LW ZY can treat IBS effectively, w hich m aybe correlate w ith m odu lating the conten t of CCK in colon tissue1 K ey w ords: irritab le bowel syndrom e; LWZY; m otility; cholecystokinin ( IBS) , LWZY IBS , , [ 1] 1 , , 111 SD 48, ( 220 ? 20) [ 2] g, , , 112 ( [ 3] ), CCKMOT IBS, LWZY : ( LWZY ) () 100 g, 200 ~ 1