Molecular markers for susceptibility to heat intolerance对热不耐受的易感性的分子标记.pptVIP

Molecular markers for susceptibility to heat intolerance Maj. Yuval Heled, PhD The Institute of Military Physiology Heller Institute of Medical Research The IDF Medical Corps Israel Genetic map for health and performance Findings the best athletes? Preventing diseases? Vision (or science fiction?) Using one small blood draw will assist in: Prevention Diagnosis Prognosis Intervention (nutrigenomics, supplements, specific training…….)? Selection…?!!! Candidate gene approach Angiotensin converting enzyme (ACE) polymorphism and the physiological response to heat challenge Heled Y et al: J Appl Physiol, 2004;97:72-6 Conclusions Molecular markers may assist in preventing physiological injuries Genetic/proteomic map of trainability and susceptibility is a future challenge * * The differences in physiological parameters changes during exposure to heat tolerance test between the two ACE genotype groups NS 648±31 660±38 Msw (g/h) =0.08 3.62±0.22 4.4±0.39 PSI 0.05 17.7±1.8 19.8±1.3 S(W.m-2) 0.05 33±7 44±5 Delta HR (bpm) 0.05 0.8±0.2 1±0.1 Delta Tre (Co) P I+ (N=33) DD (N=25) Measure/genotype Heled Y et al: J Appl Physiol, 2004;97:72-6 Heled Y et al: J Appl Physiol, 2004;97:72-6 P0.05 Heled Y et al: J Appl Physiol, 2004;97:72-6 P0.05 IL-6 Genotypes and CK response to exercise test 0 240 480 720 960 1200 Pre Post 48 Hr 72 Hr C+ (n = 77) GG (n = 62) Creatine Kinase (IU/L) * * * * * p0.03 Heled Y, Deuster P: in publication HSP70-2 Genotypes and CK response to exercise test * p0.03 Heled Y, Deuster P: in publication