Nano-Particle formation using Solution Enhanced Dispersion by 使用增强溶液分散的纳米颗粒的形成.pptVIP

Nano-Particle formation using Solution Enhanced Dispersion by Supercritical Fluid (SEDS) By Nitin Aggarwal ChE-702 Modules in Nano Pharmaceuticals Dr. Rajesh Dave Different Concepts used to Manufacture Particles RESS: Rapid Expansion of Supercritical Solutions. GAS or SAS: Gas (or Supercritical fluid) Anti-Solvent. - One specific implementation being – SEDS (‘Solution Enhanced Dispersion by Supercritical Fluids’) PGSS: Particles from Gas-Saturated Solutions (or Suspensions). ASES: Aerosol Solvent Extraction System. SEDS: A specific implementation of ASES consists in co- pulverizing the substrate(s) solution and a stream of supercritical carbon dioxide through appropriate nozzles. SEDSThe specific implementation of GAS/SASConcept The process is devised to recrystallize solid compounds that are not soluble in supercritical fluids. The polymer is first dissolved in a liquid organic solvent and a gas is employed as an antisolvent for the polymer. The gas is injected into the solution in a closed chamber and the particle precipitation occurs as the gas concentration in solution increases with pressure. The Governing PrincipleGAS/SAS/SEDS(Solvent-Induced phase Separation) Upon introduction of the antisolvent, the fluid–solid and the liquid–liquid phase boundaries are shifted to higher temperatures or higher pressures, respectively. As a result, the system which was initially in the one-phase homogeneous region finds itself in the two-phase region upon which undergoes phase separation leading to particle formation. Supercritical Antisolvent Process (SAS) A supercritical fluid acts as an antisolvent for polymer solutions as in the GAS process, but the contacting mechanism is different than that employed in the GAS process. Polymer is dissolved in a liquid solvent and the solution is sprayed into a chamber where a supercritical fluid already exists, causing rapid contact between the two