Early Embryology I - Temple University早期胚胎我-天普大学.pptVIP

The First Three Weeks Thomas A. Marino, Ph.D. Department of Anatomy and Cell Biology Temple University School of Medicine Introduction The lecture will focus on the early development of the embryo We will cover the first three weeks after fertilization. Will start with a fertilized egg. Week 1-3: Formation of: Blastocyst Bilaminar disc Gastrulation Trilaminar disc Lateral body folding Head and tail folding Vertebrate body plan Week 1: Early Embryology Week 1 The blastocyst consists of : Week 1 Week 2Day 7.5 Week 2: Early Development Human Developmental Anatomy Center Bilaminar Disc Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Gastrulation Formation of the Body AxisThe cranial end of the embryo Formation of the Body Axis Formation of the Body Axis Formation of the Body AxisLeft – Right Sidedness Cilia in Left – Right sidedness Situs inversus 20% (Kartagener syndrome) Dysfunctional cilia Respiratory problems Male fertility problems Notochordal Plate Notochord Endoderm Ectoderm Yolk Sac Amniotic Cavity Paraxial mesoderm Intermediate mesoderm Lateral plate mesoderm Anterior visceral endoderm (AVE) OTX, LIM1, HESX1 transcription factors secreted factor ceberus BMP-4 FGF BMP-4 FGF BMP-4 – bone morphogenetic protein-4 with FGF – Fibroblast growth factor Lateralize Mesoderm: Intermediate and Lateral Plate mesoderm Cranial Mesoderm Notochord Somites Somitomeres Goosecoid, chordin Noggin and follistatin Dorsalize mesoderm into Notochord and Paraxial Mesoderm Nodal HNF-3b Brachyury (T) gene Forebrain Midbrain Mid and caudal midline mesoderm development Formation of the Body Axis FGF8 Nodal Lefty PITX2 UNSW Embryology 20 days of gestation * Fertilization Day 1 2 cell stage Day 2 4 cell stage Late Day 2 Morula Day 3 Blastocyst Day 5 Implantation Day 6 - 7 /ivf/ivf_devel.htm PACIFIC FERTILITY CENTER