3dcrt低剂量区v5体积的大小对nsclc患者肺功能的影响 word格式.docxVIP

ABSTRACTObjective: By choosing 52 patients with non small cell lung cancer (NSCLC)who were treated with three-dimensional conformal radiotherapy(3D-CRT)，observing the changes oftheir pulmonary function before and afterthe radiotherapy.ηle effect of3D-CRT in the low dose region V5 volume size on pulmonary 且mction of patients with NSCLC was discussed.Methods: Collecting clinical data of 52 patients with NSCLC in 1，3，6months be岛re and after the radiotherapy who first underwent radical surgery and the success如1 completíon of three-dimensional conformal radiotherapy in our hospital oncology Department from 2014 April to 2015 October. They were divided into the following three groups in accordance with different sizein the dose volume histogram: V5 亘 45%，45%V5 三 55%，55%V565% ，setto A，B，C three groups，respectively with 20 cases，17 cases and 15 cases. The pulmonary function changes of the patients in three groups 1，3，6 months before and after radiotherapy were observed.Result: 1.The forced Expiratory volume in the first second of expiration (FEV1%) and the forced vital capacity(FVC%) ofall patients in 1 month after radiotherapy were significantly increased compared with those before radiotherapy. And the difference was significant(P0.05). The FEVl % and FVC% in 3 and 6 months after radiotherapy were decreased graduallycompared with radiotherapy after 1 month. The Diffusing Capacity for CarbonMonoxide (DLCO%) of all patients after radiotherapy was decreased compared with that before radiotherapy.2.ηle mean values ofFEVl % and FVC% before radiotherapy in 39 cases of peripherallung cancer patients w町e significantly higher than those in 13 casesof centra1 lung canc町 patients. And 由e differen臼 was SI伊ificant (PO.05).The FEVl % and FVC% of patients in two clinical types of groups in 1 mou由 after radiotherapy were higher than those before radiotherapy. And the difference was significant (PO.05). The FEVl % and FVC% of patients 3 and6 mouths after rad