基于fmri的特发性全身性癫痫的多模态网络的联合定量研究-外科学(神经外)专业论文 word格式.docx

方面，IGE 组和健康对照组在 Cerebelum_6_R 和其他 115 个 AAL 脑区之间连接值没有显著性差异。7、对病人组和对照组之间的顶点位置进行比较，发现患者左侧丘脑(P0.0286， 校正)，左侧豆状核(P0.00234，校正)和双侧苍白球(左侧，P 0.0262；右侧，P 0.0369， 校正)存在区域性萎缩。[结论]我们的研究结果表明，特发性全身性癫痫的大脑、皮层下结构、小脑均存在解剖 和功能上的改变，这可能是癫痫发病的一个重要原因。通过利用 fMRI 技术，在宏观 上活体研究癫痫患者可能的发病机制，为今后的临床诊断和治疗方面提供一些帮助。关键词：特发性全身性癫痫；白质；静息态；弥散张量成像Quantitative research of multimodal brain network connection mode in IGE based on fMRIAbstractBackgroundIdiopathic generalized epilepsy (IGE) is a group of genetically determined epilepsies. These types of epilepsies constitute nearly 15-25% of all epilepsies but show no abnormities in routine MRI examinations, although they exhibit some generalized spike and wave (GSW) or polyspike discharges against a normal background in EEG monitoring. At present antiepileptic drugs are mainly used to control such seizures as symptomatic treatment. So can we the fundamentally solve the treatment problem in idiopathic generalized epilepsy, and this depends on the in-depth study of its pathogenesis. However, there are many different pathogenesis theories about idiopathic generalized epilepsy, such as the Centrencephalic theory, Cortical theory, Corticoreticular theroy, etc., but most of these hypotheses based on different experimental animal models of epilepsy. Therefore, it is necessary to systematic analysis of the IGE brain research in vivo, so more conducive to our in-depth understanding of idiopathic generalized epilepsy.In addition, although cerebellar stimulation or vagus nerve stimulation and other surgical treatments have certain anti-epileptic effect, but the mechanism of the therapeutic effect is not clear. Some scholars speculate that the loop between cerebellar and cerebral cortex can inhabite seizure discharge. The experiments in this area are very rarely reported in the literature. Previous idiopathic generalized epilepsy research has mainly focused on animal models or molecular biology research.Materials and MethodsA total of 42 right-handed people were included