细胞因子论文关于干细胞论文.docVIP

细胞因子论文关于干细胞的论文 血浆置换对慢性乙型重型肝炎患者血清细胞因子影响的研究 　[摘要] 目的：研究血浆置换对慢性乙型重型肝炎患者血清白介素-12（IL-12）、白介素-18（IL-18）和白介素-10（IL-10）的影响。方法：40例慢性乙型重型肝炎患者，分别在血浆置换治疗前后检测血清IL-12、IL-18和IL-10的水平，同时检测肝功能、凝血酶原活动度（PTA），并与健康对照组比较。结果：慢性乙型重型肝炎患者治疗前血清IL-12、IL-18水平明显升高，IL-10水平下降（均P0.01）；血浆置换治疗后血清IL-12、IL-18水平较前显著下降，IL-10水平较前显著升高（均P0.01）。血浆置换治疗对肝功能的恢复及 PTA的升高有明显疗效。结论：血浆置换可降低慢性乙型重型肝炎患者血清IL-12、IL-18的水平，提升IL-10的水平，保护肝细胞，促进病情的恢复。 　　[关键词] 血浆置换；慢性乙型重型肝炎；白细胞介素 　　　Study of plasma exchange on serum cytokines in patients with chronic severe hepatitis B 　　DING Ningling, ZHU Xiang, WANG Yongping 　　(Department of Infectious Disease, the Fifth People′s Hospital of Suzhou City, Jiangsu Province, Suzhou 215007, China) 　　[Abstract] Objective: To study the change of serum IL-12、IL-18 and IL-10 in patients with chronic severe hepatitis (CSH) B treated by plasma exchange(PE). Methods: 40 patients were tested the level of IL-12, IL-18, IL-10 and liver function and PTA before and after PE, and compared with those of healthy control group. Results: Before PE, the level of IL-12, IL-18 in patients with CSH B went up obviously, while the level of IL-10 went down obviously (all P0.01) compared with the healthy people. After PE, the level of IL-12, IL-18 went down, while the level of IL-10 went up (all P0.01). PE treatment had obvious effect in the recovery of liver function and the increase of PTA. Conclusion: PE can reduce the level of IL-12, IL-18 and ascend the level of IL-10 in the patients with CSH B. It can protect the liver cells and help recovery for patients. 　　[Key words] Plasma exchange; Chronic severe hepatitis B; Interleukin 　　血浆置换是目前临床上广泛应用于重型肝炎的有效辅助治疗手段，我院在综合药物治疗的基础上加用血浆置换治疗慢性乙型重型肝炎，取得了较好疗效。为进一步研究其治疗重型肝炎的机制，笔者检测了40例慢性乙型重型肝炎患者治疗前后血清白介素-12（IL-12）、白介素-18（IL-18）及白介素-10（IL-10）的水平，现报道如下： 　　1 资料与方法 　　1.1 一般资料 　　选择40例我院2008年1月～2010年1月住院的慢性乙型重型肝炎患者，其中，男30例，女10例；年龄22～65岁，平均36.5岁。诊断符合2000年西安全国病毒性肝炎会议制订的诊断分型标准。选取15例我院健康体检成人为对照组。 　　1.2 治疗方法 　　患者入院后均按重型肝炎进行常规治疗，如应用促肝细胞生长素、甘草酸二铵、前列腺素E1等静脉滴注，在护肝降酶的基础上适当用新鲜血浆、白蛋白支持，并