solid-phase organic synthesis and catalysis some recent strategies using alumina, silica, and polyionic resins文档.pdfVIP

Hindawi Publishing Corporation Journal of Catalysts Volume 2013, Article ID 614829, 20 pages /10.1155/2013/614829 Review Article Solid-Phase Organic Synthesis and Catalysis: Some Recent Strategies Using Alumina, Silica, and Polyionic Resins Basudeb Basu and Susmita Paul Department of Chemistry, University of North Bengal, Darjeeling 734 013, India Correspondence should be addressed to Basudeb Basu; basu nbu@ Received 26 February 2013; Accepted 7 July 2013 Academic Editor: Raghunath V. Chaudhari Copyright 漏 2013 B. Basu and S. Paul. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Solid-phase organic synthesis (SPOS) and catalysis have gained impetus ater the seminal discovery of Merriield鈥檚 solid-phase peptide synthesis and also because of wide applicability in combinatorial and high throughput chemistry. A large number of organic, inorganic, or organic-inorganic hybrid materials have been employed as polymeric solid supports to promote or catalyze various organic reactions. his review article provides a concise account on our approaches involving the use of (i) alumina or silica, either having doped with metal salts or directly, and (ii) polyionic resins to either promote various organic reactions or to immobilize reagents/metal catalysts for subsequent use in hydrogenation and cross-coupling reactions. he reaction parameters, scopes, and limitations, particularly in the context of green chemistry, have been highlighted with pertinent approaches by other groups. 1. Introduction of drug discovery and research [24鈥?6]. he solid-phase