该表达出再复发的患者.pdfVIP

RCT RCT RRCCTT文章评析 Thetreatmentofrelapsingprimarynephroticsyndromeinchildren 复发儿童肾病综合症的治疗 评析：全文一直在讨论再复发的治疗，并且选用雷公藤多甙片这一新 的中药治剂干预治疗，与目前临床疗效确切的CTX相比较，文章名与内容 并不是很贴切，没有准确反应内容。 Thestudyonre-relapsingprimarynephroticsyndromeinchildren (withtripterysiumglucosides) ABSTRACT ABSTRACT AABBSSTTRRAACCTT 摘要 Objective: To explore better therapy and reduce re-relapse rate of primary nephritic syndrome in children had been treated with corticosteroids but relapsed. Methods:Eightyrelapsers wereenrolledfromJan. 1994toApr.2000,were randomized into two groups.The treatment group (n=39) had been treated with tripterysium glucosides for three months, with the control group (n=41) members were treated with cyclophosphmide (CTX) by intermission intravenous pulse, with total dose of CTX not being more than 150 mg/kg. Prednisone,meanwhile,was given to both groups.The total treatment period of prednisonewasprolongedby12–18months. Results: After following up for 3–7 years, the re-relapse rates of both groups were observed.The re-relapse rate of the treatment group was 28.2% to 29.3% in the CTX-controlled group. The re-relapse rates between two groups were almost similar, and with no observed significant difference (P0.05).The sideeffectoftripterysiumglucosideswaslessthanthatofCTX. Conclusion: Forthe treatment of relapsing nephritic syndrome in children, thecombinationoftripterysiumglucosidesandprolongedcorticosteroidtherapy isaseffectiveastheregimenofCTXplusprolongeduseofprednisone. 评析：文摘格式正确，符合中文文摘格式，文字表达主题不确切，应 1 该表达出再复发的患者，应用不同的疗法（雷公藤多甙与CTX）的临床疗 效，或者直接表达出雷公藤多甙的临床疗效，因为分组时是以雷公藤多甙 组为治疗组，CTX为对照组，而且CTX临床得到认可，作者临床应用雷公 藤多甙有效，又有低副作用的优势，而且全文显示出的研究目的也是为了 证雷公藤多甙的疗效。 Keywords: Primary nephrotic syndr