维生素C及其衍生物在药物及载体靶向修饰中的应用.pdfVIP

Pharmacy Information 药物资讯, 2017, 6(2), 17-24 Published Online May 2017 in Hans. /journal/pi /10.12677/pi.2017.62004 The Application of Ascorbic Acid and Its Derivatives in Targeting Modification of Prodrug and Drug Delivery Carrier Siyuan Hu, Fanglian Yi, Libiao Luan Department of Pharmaceutics, China Pharmaceutical University, Nanjing Jiangsu th th rd Received: Apr. 15 , 2017; accepted: Apr. 30 , 2017; published: May 3 , 2017 Abstract As a nature antioxidant and an important conferment involved in the metabolism, ascorbic acid is commonly used and has gained immense attention recently for its targeting ability. In the present article, we reviewed and summarized relevant research that investigated the potential of ascorbic acid and its derivatives to act as targeting ligand while being modified into prodrug and drug de- livery carrier, and we look forward to providing the proper construction of targeting drug delivery system with new prospective and methods. Keywords Ascorbic Acid, Targeted Prodrug Modification, Targeted Drug Delivery Modification 维生素C及其衍生物在药物及载体靶向修饰中 的应用 胡思源，易芳莲，栾立标 中国药科大学药剂学实验室，江苏 南京 收稿日期：2017年4月15 日；录用日期：2017年4月30 日；发布日期：2017年5月3 日 摘 要 维生素C作为天然抗氧化剂以及体内代谢的重要辅酶，用途广泛，近年来因其作为前药靶向修饰剂备受 文章引用: 胡思源, 易芳莲, 栾立标. 维生素C 及其衍生物在药物及载体靶向修饰中的应用[J]. 药物资讯, 2017, 6(2): 17-24. /10.12677/pi.2017.62004 胡思源 等 关注。本文对近年来国内外相关研究文献进行分析、归纳，总结维生素C及其衍生物在药物及载体靶向 修饰中的应用，以期为合理设计靶向药物分子提供思路和方法。 关键词 维生素C，靶向药物结构修饰，载体靶向修饰 Copyright © 2017 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Open Access 1. 引言 为解决药物生物利用度低、药物代谢参数不理想等问题，化学家将药物活性成分进行合理修饰，设 计成前药。随着对分子生