生物奥赛之生物化学重点串讲-----激素对代谢的调节作用.ppt

激素对代谢的调控作用 Regulation of PFK-2 and FBPase-2 activity Insulin Regulation Insulin can block GSK3 for activation of glycogen synthase Insulin can activate PP1 for activatation of glycogen synthase * * 内分泌 自分泌 旁分泌 Both neurotransmitters and hormones interact with specific receptors on or in their target cells, triggering responses. Regulation of PFK-2 and FBPase-2 activity Regulation of glycogen phosphorylase by epinephrine and glucagon Regulation of glycogen phosphorylase and glycogen synthase by epinephrine and glucagon Glycogen breakdown The Pancreas Secretes Insulin or Glucagon in Response to Changes in Blood Glucose Glucose regulation of insulin secretion by pancreatic ? cells. The well-fed state: the lipogenic liver The fasting state: the glucogenic liver Fuel metabolism in the liver during prolonged fasting or in uncontrolled diabetes mellitus