骨结合Osseointegration.pptVIP

OSSEOINTEGRATION “Reconstructive Biology” Not “Carpentry” 1960 Professor Branemark, Goteborg University, Dept of Anatomy PI offered the posistion of Professorship, research poition Continued his research, this time tot the related topic of microcirculation of blood Picture 1; 20 volunteers, mostly students, agreed to have tiny Ti chambers, surgically inserted into their upper left arms. In situ for between 3-7 months. Picture 2 In order to insert the chambers in the arm, a plastic surgeon had to create a tube of skin in the upper arms, which would provide enough room to fit the chamber Picture 3 A volunteer is being examined Ischemia experiments Study how the blood vessels repar themselves after trauma Picture 1 Skin tubes with microcusffs connected to microsope Picture 2 Inflammatory response Cuffs are released after six hours Picture 3 Red blood Cells in low flow situation Picture 4 Recovery 24 hours later showing recovery of the compressed tissue and maintained integration of the chamber in the skin tube Branemark and his team were surprised that the Ti chambers, after being in place in soft tissue for so long did not cause any adverse reaction. The body did not appear to regard this foreign material other than its won. No infection and rejection MAIN POINT Branemark realised that Ti could be used for medical applications because of its apparent acceptance without adverse reaction both by hard and soft tissue. With the ultimate aim of treating humans, Branemark, set about carrying out new sets of experiments which would prove or disprove his belief that Ti could be used successfully over a long period of time in the living body…\ Individual Components and Surgical Instruments Different prototypes of fixture designs Branemark began his famous beagle dog studies MAIN POINT: During these animal studies the following guidelines were developed: Basis of 2-stage surgical technique approach Handling of living bone (irrigation, temperature control) No pr