缺血性脑卒中／TIA 二级预防抗血小板药物规范化应用的中国专家共识资料.pptVIP

* In CAPRIE,1 8,854 patients had a prior history of any ischemic event, and of these 4,496 had a history of a major acute event – a myocardial infarction or a stroke.1 The annual event rate per 1,000 patients was reduced in the clopidogrel group vs the ASA group by 34 in patients with a prior history of a major acute event, and by 28 in those with a prior history of any ischemic event, compared with 11 in the overall population.1,2 The benefits of clopidogrel over ASA were amplified in the higher vascular risk group.3 References: 1. CAPRIE Steering Committee. Lancet 1996; 348: 1329–39. 2. Jarvis B, Simpson K. Drugs 2000; 60: 34–77. 3. Ringleb PA. Eur Heart J 1999; 20: 666. * * 23.01.08 PAR * 23.01.08 PAR * * Pathogenesis of ICAS related infarction is different from SAD, and CE Unstable plaque (often with mixed mechanisms) A-A embolism Penetrating A occlusion Hypo-flow Usually + microemboli * Pathogenesis of ICAS related infarction is different from SAD, and CE Unstable plaque A-A embolism Penetrating A occlusion Hypo-flow, usually + microemboli * Pathogenesis of ICAS related infarction is different from SAD, and CE Unstable plaque A-A embolism Penetrating A occlusion Hypo-flow, usually + microemboli * Pathogenesis of ICAS related infarction is different from SAD, and CE Unstable plaque A-A embolism Penetrating A occlusion Hypo-flow, usually + microemboli Mixed mechanisms * Wong KS. Use of Transcranial Doppler Ultrasound to Predict Outcome in Patients With Intra-cranial Large-Artery Occlusive Disease. Stroke. 2000, 31(11): 2641-7 Risk of death and recurrent vascular events at 6 months Risk at pts with occlusion with stenosis without stenosis 705 cases * Long term outcome of IS due to ICAS Wong KS. Long-Term Mortality and Recurrent Stroke Risk Among Chinese Stroke Patients With Predominant Intracranial Atherosclerosis. Stroke. 2003; 34: 2361-2366 * Outcome of IS due to ICAS or LAD Petty GW, et al. Ischemic Stroke Subtypes: A Population-Based