boldmri与脂肪肝.docVIP

Carbogen Gas–Challenge BOLD MR Imaging in a Rat Model of Diethylnitrosamine-induced Liver Fibrosis1 Ning Jin, MS, Jie Deng, PhD, Tamuna Chadashvili, PhD, Yue Zhang, BS, Yang Guo, MD, Zhuoli Zhang, MD, Guang-Yu Yang, MD, PhD, Reed A. Omary, MD and Andrew C. Larson, PhD + Author Affiliations 1From the Departments of Radiology (N.J., J.D., T.C., Y.Z., Y.G., Z.Z., R.A.O., A.C.L.), Biomedical Engineering (N.J., J.D., R.A.O., A.C.L.), and Pathology (G.Y.Y.), and Robert H. Lurie Comprehensive Cancer (R.A.O., A.C.L.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Medical Imaging, Children’s Memorial Hospital, Chicago, Ill (J.D.); and Department of Bioengineering, University of Illinois at Chicago, Chicago, Ill (Y.Z.). Address correspondence toA.C.L. (e-mail: a-larson@). Author contributions: Guarantors of integrity of entire study, Z.Z., A.C.L.; study concepts/study design or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for important intellectual content, all authors; manuscript final version approval, all authors; literature research, N.J., J.D., T.C., Y.Z., Y.G., Z.Z., A.C.L.; experimental studies, all authors; statistical analysis, N.J., J.D., Y.Z., Y.G., Z.Z.; and manuscript editing, N.J., J.D., Y.Z., Y.G., Z.Z., G.Y.Y., A.C.L. ? Next Section Abstract Purpose: To investigate the relationship between gas-challenge blood oxygen level–dependent (BOLD) magnetic resonance (MR) imaging measurements and hepatic disease progression in a rat model of diethylnitrosamine (DEN)-induced liver fibrosis. Materials and Methods: The institutional animal care and use committee approved all experiments. Liver fibrosis was induced in 27 male Wistar rats by means of weekly oral gavage with 5 mL of 1.5% DEN solution per kilogram of body weight for 3–11 weeks, which produced varying degrees of liver fibrosis. Eight rats developed nonsubstantial fibrosis（非物质性的纤维化）; eight rats,