10、抗感染免疫.pptVIP

Development of the Immune System Balance between Infection and Immunity Response to Infection Components of Innate and Adaptive Immunity Characteristics of Innate and Adaptive Immunity No Immunologic memory Nature killer/ NK cell NK cells are Activated by IFN-alpha/beta NK cells are not restricted by MHC Its killing is non-specific NK cell Complement Enhancing neutralization of Antibody Enhancing phagocytosis of virus particles Properties of human interferons Activities of interferon Antibody 3) Neutrilizing antibody Mechanism: Concept: --- prevent the the interaction of the virus with cell receptors --- cross-link the viral proteins --- Prevent uncoating --- lysis of virus infected cells * * ery pl mye neu mφ lym nk thy CD8+ CD4+ CTL TH2 TH1 Components of the Immune System Humoral Cellular Humoral Cellular Specific Nonspecific complement, interferon, TNF etc. macrophages, neutrophils T cells; other effectors cells antibodies infection immunity Bolus of infection x virulence immunity Disease = infection x disease Innate immunity no disease recovery adaptive immunity re-infection no disease x Innate Immunity Adaptive Immunity skin, blood-brain, blood-placenta many protein and non-protein secretions macrophage, NK cell Neutrophil physical barriers soluble factors cells none Immunoglobulins (antibody) T and B lymphocytes 内毒素被解毒 醋酶 血清 内毒素解毒因子 多种细菌 肽蛋白质 血清 正常调理素 革兰阳性菌 蛋白质 乳汁 乳素 革兰阳性菌 碱性多肽 膜、肾、前列腺 精素、精胶碱 需铁细菌 假球蛋白 血清 转铁蛋白 革兰阳性菌 含铁叶琳 红细胞 正铁血红素 革兰阳性菌 碱性多肽 血小板 血小板素 革兰阳性菌 碱性多肽 中性粒细胞 白细胞素 革兰阴性菌 碱性多 淋巴系统 组蛋白 多种细菌 碱性多肽 中性粒细胞 吞噬细胞杀菌素 革兰阳性菌 血清 乙型溶素 革兰阳性菌 碱性多肽 吞噬细胞榕酶体、唾液、泪液、乳汁等 溶菌酶 正常球蛋白 血清 补体 作用对象 化学性质 主要来源 抗菌物质 正常体液与组织中的抗菌物质 细胞核 Chemotactic response to inflammatory stimulus Macrophage Attacking E.coli (SEM x8,800) Adaptive Immunity Innate Immunity Adaptive Immunity Antigen independent No time lag Not antigen specific Antigen dependent A lag period Antigen specific Development of memory Type of infection Type of immunity Extracellular bacteria An