database生物信息数据库.ppt

NCBI Molecular Biology Resources Mouse Assembly concept Cytogenetic map Genetic map (linkage map, genetic linkage map) Physical map Sequence map The Map Viewer supports search and display of genomic information by chromosomal position. Regions of interest can be retrieved by text queries (e.g. gene or marker name) or by sequence alignment (BLAST). View results at the whole genome level, and select what to display in more detail. Multiple options exist to configure your display, download data, navigate to related data, and analyze supporting information using the tools provided MapViewer: Human ADAR Maps Options Maps Options Genomic Synteny Download Sequence: dl Link Entrez Gene Global Entrez: Search for HFE Entrez Gene Record: Human HFE Gene Graphic Links Introns/Exons: Gene Table The HomoloGene No longer UniGene based Protein similarities first Guided by taxonomic tree Including orthologs and paralogs Incorporated in Entrez system XML formatted ftp file Paralogs vs Orthologs HFE → HomoloGene Homolgene: HFE – domain conservation Links To UniGene from HomoloGene heterozygosis Check to add new screen shot with SNPs Diff from LL 1) all RefSeq genomes 2) integrated into Entrez can query on names, symbols, accessions, publications, GO terms, chromosome numbers, E.C. numbers, and… Eukaryotes only? Add the Adar comparison between human, mouse and rat Add URL Take a look at gene table and know the buttons For organisms with no refseq genomes, one can still get info using the “UniGene links” (or look under the UniGene section) * NCBI FieldGuide RefSeq Contig BAC WGS Other GenBank RefSeq Transcript UniGene Transcript /mapview/ --Sequence maps-- Ab initio Assembly BES_Clone Clone Contig Repeats Component CpG island dbSNP haplotype Fosmid GenBank_DNA Gene Phenotype SAGE_Tag STS TCAG_RNA Transcript (RNA) Hs_UniGene Hs_EST --Cytogenetic maps-- Ideogram FISH Clone Gene_Cytogenetic Mitelman Breakpoint Morbid/Disease --Genetic Maps-- deCODE Genethon Mars