erα erβ 和 ki67在甲状腺癌中的表达及意义word格式论文.docx

目录中文摘要············································································································1英文摘要············································································································4英文缩写············································································································8研究论文ERα、ERβ和Ki-67在甲状腺癌中的表达及意义前言············································································································9材料与方法······························································································11结果··········································································································14附图··········································································································16附表··········································································································21讨论··········································································································24结论··········································································································27参考文献··································································································28综述ERα、ERβ和Ki-67在甲状腺癌的研究进展······································32致谢··················································································································44个人简历··········································································································45ERα、ERβ和Ki-67在甲状腺癌中的表达及意义摘要目的：甲状腺癌约占全世界所有癌症的2%和95%的内分泌癌。甲状腺癌是2000年以来发病率增长最快的实体癌。甲状腺癌的发病率有明显的性别差异，女性表现出更高的检出率及增长趋势。育龄期女性甲状腺癌的发病率显著高于绝经后女性。因此甲状腺癌可能是激素依赖性肿瘤。雌激素通过雌激素受体α（Estrogenreceptoralpha）与雌激素受体β（Estrogenreceptorbeta）作用于甲状腺癌细胞，调控甲状腺癌的发病、转移、侵袭。Ki-67 抗原是目前已知的反应细胞增殖能力并应用最广泛的增殖细胞标记物之一。Ki-67与有丝分裂关系密切且大量研究表明Ki-67的高表达与年龄、肿瘤大小肿瘤侵袭倾向、淋巴结转移等均有关系。本实验通过检测ERα、ERβ、Ki-67在甲状腺癌中的表达来探讨其在甲状腺癌的发生发展中起到的作用及相关性，为甲状腺良恶性鉴别、临床预后提供理论依据。方法：1选取河北医科大学第三医院2006-2015年间临床病理资料完整、由经验丰富术者施行病例80例，