Chapter 1, Mechanism of Organic Reaction 高等有机化学教材.pptVIP

Notice(1)All Homework info. : Group Projectsindividual homeworkEmail to: chem_homework1@126.com Slides Materials May available on/jkyang /AOC_Chapt1_5_050929.ppt HxHg_Gucas@126.com NewPassword: Group Project member listin Access Notice(2)No Class during10/1~10/7/2005 10/8/2005 ( Sat.周六 ) will have the class for 10/6/2005(Thu周四) Advanced Organic Chemistry(1)高等有机化学（I） Instructor: JingKui YANG 杨镜奎 College of Chemistry and Chemical Engineering Graduate University of CAS (GUCAS) Main Topics in 9/26 Reversible Reactions Kinetic controlling(动力学控制) Thermodynamic( equilibrium) Controlling (热力学控制) Hammond Hypothesis: exothermic(放热） endothermic(吸热): transition state and starting ducts Selectivity relation Carbocation Stability PIE(Primary Isotopes Effects), SIE  (Secondary Isotopes Effects)KH/HD,  Biggest Isotopes Effects(IE) and symmetric  transition states  Main Topics in 9/26 Principle of Micro-reversibility 微观可 逆性原理: elementary reactionThe Markovnikov Rule The Curtin Hammett Principle : product ratio and Reactants equilibrium ( conformer ) and activated free energy  Main Topics in 9/26 1.3.6 Substituted Group Effects Electron effects Steric effect Linear Free Energy Relation_Hammett Equation Taft Equation ρ and mechanism Aromatic Electrophilic substitution _Structure/reactivity Radical Chem.Substitution effects: Hammett 1.3.6 Substituted Group Effects Electron effects steric effects Electronic Effects 电子因素 (withdrawing or donating: Inductive Effects(诱导效应） Fields Effect（场效应） Conjugated Effected(共轭效应） HyperConjugation(超共轭效应) Space Interaction: Steric Effects( 立体空间效应) 空间因素 Field Effect in long distance (远距离场效应) Hinder effect(size or shape of groups) 位阻效应 σ,π π .1 Inductive/Field Effects: INDUCTIVE effects(IE) are those that occur through the sigma system due to electronegativity effects.  IE: This influences on the electron distribution in σ bonds These too can